Thalidomide-O-amido-PEG3-C2-NH2 TFA ( Cereblon Ligand-Linker Conjugates 3 (TFA); E3 ligase Ligand-Linker Conjugates 14 TFA )

Catalog No. M23888 CAS No. 1957236-21-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Thalidomide-O-amido-PEG3-C2-NH2 TFA
Note

Research use only, not for human use.
Brief Description

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
Description

Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
Synonyms

Cereblon Ligand-Linker Conjugates 3 (TFA); E3 ligase Ligand-Linker Conjugates 14 TFA
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

Cereblon
Research Area

——
Indication

——

CAS Number

1957236-21-3
Formula Weight

620.5
Molecular Formula

C25H31F3N4O11
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL (80.58 mM; Need ultrasonic)
SMILES

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCN.C(=O)(C(F)(F)F)O
Chemical Name

——

1.BRADNER, James, et al. METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES. WO2017024317A2.

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